I have been reading alot about this stuff and was wondering if I should give it a try. I found this on another forum somewhere:

Femara (AKA Letrozole), is more effective than Arimidex in it's ability to pass thru the cell membrane of lipid (fat) cells and inhibit the activity of aromatase -- Arimidex is just over 80% effective at inhibiting aromatase, Femara is around 95-97% Levels of estrogen are totally undetectable in any patients taking Letrozole, and it has even been used to increase testosterone to normal levels (from sub-normal ones) and increase LH, FSH and SHBG (1). Other than that, both of these drugs stop the process of aromatization, rather than just blocking (competing for, if you prefer) the receptors as Clomid and Nolvadex do. An effective dose of Letrozole is .100mgc (6)-2.5 mg/day (I use .25mg/day), but be forewarned, it can kill your sex drive, and could decrease IGF levels. On the other hand, I've seen studies where it increases IGF levels. Also worth noting is that there's a rebound effect when you come off Letrozol. What can I say? Letrozole's effects on serum lipids (cholesterol, both HDL and LDL) are, in the words of one researcher: "inconsistent. "And compared with Aromasin and Arimidex, In non-cellular systems, letrozole is 2-5 times more potent than anastrozole and exemestane in its inhibition of the aromatase enzyme and activity, and in cellular systems it is 10-20x more potent! Letrozole (2.5mg daily) also achieved a much greater suppression of the plasma concentrations of both estrone and estrone sulphate (estrogens) than anastrozole (1mg daily) and a greater inhibition of in vivo aromatization also (sorry for the geek-speak.it's over for now.)(2) Exemestane can also cause androgenic sides (3)(4)(5)I've used Letrozole, and it cleared up my minor gyno lumps, to the point that they are totally gone now.
1.Epilepsy Behav. 2004 Apr;5(2):260-3
2.J Steroid Biochem Mol Biol. 2003 Oct;87(1):35-45
3.Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S.
4.J Clin Endocrinol Metab 2000 Jul;85(7):2370-7 2.
5.J Steroid Biochem Mol Biol 1997 Nov-Dec;63(4-6):261-7)

I know that you can get this stuff in liquid form for about the same price as Tamoxifen Citrate. What do you guys think about it? Also, would you just take it orally like tamoxifen?

cure NO! prevent YES!

Only Nolvadex can cure "developing" gyno. Once you have permanent gyno, there is no cure except surgery.

lance said it... letrozole is some powerful stuff too. nothing like nolva. it can actually drop your estrogen level down to nothing (which isn't good)

it works very very well in small doses

But I have just been reading alot about how letrozole is better than nolvadex for gyno. A few people have been saying that it reduced the lumps under their nipples to almost nothing. Is it ok to take this with nolva while on cycle or is that overkill?

Fair enough, but I've yet to hear of someone whos had gyno for many years, pubertal or otherwise, where any drug helped.

I know none of that shiz works for me, and I've tried IT ALL.