Sunifiram |
Bulk Nutrition Forums > Supplements |
| Posted by: Kile19065 May 19 2004, 04:18 AM |
| I love the fact that you guys offer Piracetam powder but I've been looking into Piracetam-like compounds simply so I don't have to taste so much bitter substance (yes I know I could cap it, but going into the local GNC as a 19 y/o buying gelcaps earns me dirty looks). Anyone else that has some interest in potent Piracetam related supplements like Sunifiram or Unifiram please express your interest so that we can see these things come out to the public! Here is some literature for the lazy  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12070754&dopt=Abstract |
| Posted by: Abraham21815 May 19 2004, 02:02 PM |
| I think this is as close as I'll get to creaming my pants over a nootropic, in all seriousness though you've really got me thinking about this compound. |
| Posted by: Utmost Certainty May 19 2004, 05:50 PM |
| Any tests on toxicity done with sunifram? You might want to check that out before you get too gungho about taking it. |
| Posted by: Abraham21815 May 19 2004, 06:32 PM |
| http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed edit: Search "Sunifiram" and read the few articles available on it. Check this shit out, impressive. I don't think we have to worry about our testicles like with Nefiracetam. |
| Posted by: Geffen May 19 2004, 09:07 PM |
| Sounds like some potent stuff! I wonder why we haven't heard more about sunifiram? It's supposedly way beyond piracetams power. |
| Posted by: Kile19065 May 20 2004, 05:12 PM |
| Because it's not marketed publicly. I found quite a few medical journal abstracts, but I couldn't find a single website claiming to carry this potent material. Perhaps they figure that since it's so potent, you wouldn't come back to buy more in a long while? Hard to tell... |
| Posted by: Abraham21815 May 20 2004, 07:22 PM |
| It seems far more potent than even Pramiracetam, I'd love to read more studies on it though. |
| Posted by: shpongled May 21 2004, 11:40 AM |
| All right... time for a reality check. The reasons I don't think offering sunifiram would be a good idea: 1. It is no doubt patented, and since it is a new pharmaceutical, there is a high likelihood that any company that tries to sell it would get sued ASAP. 2. Potency does not necessarily correlate with maximal activity. Racetam nootropics tend to have bell-shaped dose-response curves. So the question you want answered is not how potent a compound is, but how strong the effect is at the dose which has the maximal effect. For example, some steroids that are considerably more potent on an mg per mg basis are much less desirable in terms of effects. Accordingly, here is a quote from one of the sunifiram studies: The maximal antiamnesic effect of DM235 was obtained with the dose of 0.001 mg kg–1 i.p. and maintained up to 0.1 mg kg–1 i.p. The DM235-induced antiamnesic effect was of the same intensity as that exerted by the well-known nootropic drugs piracetam (30 mg kg–1 i.p.), aniracetam (100 mg kg–1 p.o.) or rolipram (30 mg kg–1 p.o.) (Fig. 2A and  .3. There are no human studies on this compound. So we know nothing about the toxicity, side effects, or pharmacokinetics in humans. I agree that it is promising, but self-experimentation with drugs like this - especially ones with an active dose of 1 mcg/kg - is dangerous. Not only that, but with a bell-shaped dose response curve, you have to hit a very narrow dosage range to achieve an effect, which is much more difficult if the doses are miniscule. It is possible that even a fraction of a milligram too much could make it so it had no nootropic effect at all. |
| Posted by: Abraham21815 May 21 2004, 05:45 PM |
| I have cautious optimism for this compound. If it's pretty soluble then it would not be an issue dosing at 1mcg/kg. This would simply be a matter of dissolving it in a large container of water, or through dilute the dilute further until you have the appropriate concentration and dosage. As I said before, though, I want to read more studies, especially human studies. |
| Posted by: Vanessa30161 Jun 1 2004, 04:53 PM |
| Definitely Pramiracetam powder... I haven't had that in years, it was very expensive, but Wow I never had such motivation from a pill before that wasn't a CNS / jittery stimulant like caff/eph. Also, Centrophenoxine its like supercharged DMAE definitely noticable results w or w/o a 'racetam stack and Idebenone. I noticed these 2 powders already available on another site. |
| Posted by: Prune Jan 11 2005, 06:31 AM |
| Damn, there are SOOO many of them! http://www.bentham.org/sample-issues/cpd8-2/gualtieri/gualtiei-ms.htm So, any thoughts on homebrewing any of the hard-to-impossible to buy ones? |
| Posted by: paladin Sep 12 2007, 09:27 AM | ||
anyone know who manufactures sunifiram |
| Posted by: Jason97 Jul 13 2008, 09:07 PM |
| http://www.ncbi.nlm.nih.gov/pubmed/12070754 WOW! Let's get this stuff like yesterday! |