There's no evidence to take it with a sugar or carbo to boost insulin levels. This won't preferentially shuttle more BA towards the muscle. The same would apply to NO boosters as well. Absorption doesn't appear to be hindered if it's taken on an empty or full stomach either. So the most important factor is dosage and ranges from 3.2-6.4g based on clinical trials. It may be best to split it into several doses but that's moreso to
prevent paresthesia(tingling). So as long as you take the prescrived dose it really doesn't matter how or when you take it.