Primary effect of
glutamine supplementation appears to be that it *maintains* muscle cell mass and volume (primarily
protein anti-degradant, is osmotically active in regulating water balance, and is a relatively weak cortisol inhibitor) during events which could result in catabolism. Some evidence for immuno-regulatory action. It (
glutamine) comprises 50% of the amino acid pool in some tissue types (such as heart muscle) and is therefore necessary for
protein synthesis for these cells. It is not very stable in solution; dilute solution uptake by gut may not be high, which may explain the variable success reported in the medical literature and by consumers.
Decent on-line reference:
http://www.paulun.se/paulun_pop.asp?idContent=262Interesting recent article:
http://jap.physiology.org/cgi/content/full/93/4/1251Glutamate ingestion and its effects at rest and during exercise in humans
Marina Mourtzakis and Terry E. Graham. Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1. J Appl Physiol 93: Vol. 93, Issue 4, 1251-1259, October 2002
Good on-line citation list for recent medical reports of
glutamine impact on exercise physiology and
immune system response:
http://www.oznet.ksu.edu/pr_suppl/athletes/glutamine.htm