a sticky with this info would be great.

all of them too.

what google?

Anastrozole, also known as Arimidex, is a Competitive Non-Steroidal Aromatase Inhibitor. This means that it blocks the Aromatase Enzyme.

It is Aromatase that is chiefly responsible for converting Testosterone to Estrogen. It is used clinically for treatment of estrogen dependent tumors in post menopausal women.

Anastrozole is remarkably powerful, as a single daily dose of 1mg can render upwards of 80% Estrogen suppression in test subjects. Less is more when it comes to responsibly using this for research. One half, or even one quarter of that dose is effective for most research


Clenbuterol is marketed as a Bronchiodilator. It is classified as a Selective Beta-2 Sympathomimetic. This means that it affects the Sympathetic Nervous System, more specifically, the Beta-2 Adrenoreceptor. While this primarily was used to treat patients with respiratory problems, the Beta-2 Adrenoreceptor agonists can be strongly thermogenic. This means that Clenbuterol can break down triglycerides in fat cells to form free fatty acids. In short, it is a potent fat burner.

Although it is classified as selective to the Beta-2 Adrenoreceptor, it can still exert effects on other Beta Receptors, some effect is noted on Beta-1, which would affect cardiac function.

One should be very wary when using Clenbuterol for research, as directly stimulating the CNS to this degree has many drawbacks. The research subject can get body tremors, increased sweating, nausea, increased blood pressure and if overdosed, cardiac arrest is a real concern.

Less is more with this compound as with anything.


Clomiphene Citrate is the active ingredient in Clomid. It is a SERM, (Selective Estrogen Receptor Modulator). It is commonly prescribed to women as a fertility aid.

In certain tissues, it can block the ability of Estrogen to bind with it's receptor. This blocks Estrogen's negative feedback effect on the HPTA (Hypothalamus-Pituitary-Testicular Axis) in men, or HPOA (Hypothalamus-Pituitary-Ovarian Axis) in women. This results in the release of Leutinizing Hormone and Follicle Stimulating Hormone. For men this means an increase in natural Testosterone Production. In women this will result in inducing ovulation.

Clomiphene Citrate is selective to breast tissue, and will block estrogen from binding to it's receptor there.


Finasteride is known as the brand name Proscar. It selectively inhibits the 5a-reductase enzyme. This is the enzyme that converts Testosterone to Dihydrotestosterone, known as DHT for short.

Since it is selective to the 5a-reductase enzyme only, it has little if any effect on other hormones in the body.

It is quite efficient at it's job, and effectively reduces the level of DHT in test subjects. It is used for Prostate Enlargement and Male Pattern Baldness, as DHT is the main culprit in both conditions.


Exemestane, aslo known as Aromasin, is in a class known as Steroidal (or irreversible) Suicide Aromatase Inhibitors. This means that it binds and permanently renders the enzyme Aromatase inactive. Aromatase is the enzyme responsible for converting Testosterone to Estrogen in a process known as Aromatization.

By rendering any Aromatase it comes in contact with inert, Estrogen levels should drop considerably in research subjects.

Exemestane has a favorable profile for research, as it does not have as much adverse lipid profile changes as the other AIs.

In short, Exemestane is effective at managing Estrogen in test subjects.

Letrozole is the active ingredient in the brand name Femara. It is a Competitive Non-Steroidal Aromatase Inhibitor, much like Anastozole. It will bind and block the Aromatase Enzyme.

Aromatase is responsible for converting Testosterone to Estrogen. Letrozole's clinical purpose is to treat Estrogen dependent tumors in post menopausal women.

Letrozole is extremely effective at suppressing Estrogen levels in tests. Clinical trials have shown 0.5mg to suppress 78% of Estrogen. A little goes a long way, as you can see. For research purposes, it is best to ascertain the lowest effective dose.


IGF-1, or Insulin-like Growth Factor-1, is a peptide hormone found naturally in the human body. The Lr3 means that there is an addition of Arginine at Residue 3 and an N Terminal extension, resulting in a longer half life than regular IGF-1.
IGF-1 stimulates growth, more namely, cell hyperplasia... or the making of new satellite cells. This increase in satellite cell activity, muscle DNA content, and muscle protein content results in more muscle, or rather, the ability to put on more muscle.

IGF-1 stimulates growth in all tissues, barring the brain and eyes.

IGF-1 is the mediator of all anabolic acticity of Growth Hormone. Growth Hormone actually stimulates the release of IGF-1. and therein lies the hyperplasiac and hypertrophic effects that Growth Hormone is known for.

Lr3IGF-1 is for research only. Each kit includes 1000mcg (1mg) of Lr3IGF-1, 2ml of Acetic Acid for reconstitution, and 10ml of NaCL (sodium choride for dilution purposes **optional**)


Sildenafil Citrate is the active ingredient in Viagra, the famous drug for erectile dysfuncion.

Sildenafil is a selective inhibitor of cGMP specfic Phosphodieterase type 5 (PDE5).

PDE5 is responisble for degradation of Cyclic Guanosine Monophosphate (cGMP)

cGMP is responsible for vasodilation, or relaxation, of blood vessels and smooth muscle. This along with increased Nitic Oxide results in increased bloodflow and an erection.

To put it simply, Sildenafil is quite effective at inhibiting cGMP, which allows the user to have erections quite easily.



Tadalafil is used to treat erectile dysfunction. It is the active ingredient in Cialis.

Tadalifil works much like Sildenafil, but has a half life of 17.5 hours. Also, 20mg of Tadalifil is comparable to 100mg of Sildenafil.

Tadalafil inhibits cGMP specific Phosphotiesterase type 5 (PDE5)

PDE5 is responsible for degradation of Cyclic Guanosine Monophosphate (cGMP)

cGMP is responsible for vasodilation, or relaxation, of blood vessels and smooth muscle. This along with increased Nitic Oxide results in increased bloodflow and an erection.

Tadalafil is extremely effective in treating erectile dysfunction, by inhibiting cGMP. It's effects will last much longer than it's cousin, Sildenafil.

Tamoxifen Citrate is the active ingredient in Nolvadex. It is a SERM, or a Selective Estrogen Receptor Modulator. This means that it blocks Estrogen receptors in certain tissues. It is used clinically to treat women with Estrogen receptor positive breast cancer, or as a preventative measure against breast cancer in people that have high incidence of it in their families.

Due to it's Estrogen receptor blocking capabilities, it can halt the negative feedback inhibition that Estrogen has on the HPTA (Hypothalamus-Pituitary-Testicular-Axis)in men, and the HPOA (Hypothalamus-Pituitary-Ovarian-Axis) in women. This will result in a higher release of Leutinizing Hormone and Follicle Stimulating Hormone, which in turn causes men to produce more Testosterone in their Leydig's cells, and causes women to ovulate.


Toremifene Citrate is the active ingredient in Fareston.

Toremifene is a Selective Estrogen Receptor Modulator (SERM), much like Tamoxifen and Clomiphene. It is used for the same purpose clinically, which is the treatment of Estrogen receptor positive (or receptor unknown) breast cancer in post menopausal women. It is one of the newer compounds approved for this use. Being selective, it is an Estrogen Receptor Antagonist in Breast tissue, but has shown to be an Estrogen Receptor Agonist in the Liver.

It has been noted that of the positive Estrogenic effects selective to the liver that Toremefine, Tamoxifen, and Clomiphene possess, Toremefine has been shown to be stronger. This means a positive effect on Cholesterol that at least rivals that of the others

all of this is from chemone.

please sticky

Ketotifen

"Ketotifen was made popular by its ability to inhibit the down regulation of beta receptors caused by drugs like clenbuterol. Clenbuterol, albuterol, and Ephedrine used to be cycled on and off because they desensitize the various receptors they act on to produce their lipolytic effect. Ketotifen would therefore allow the use of these fat burning drugs for much longer periods.


Ketotifen, in medical circles, is also recognized for its ability to lower levels of the cytokine Tumor Necrosis Factor-alpha (TNF-alpha), which is a catabolic hormone, and this is a property that Benadryl does not have to my knowledge. TNF-alpha lowers both testosterone and IGF-1 levels (3) (4), and strenuous exercise elevates TNF-alpha levels (5). TNF-alpha has also been shown to increase insulin resistance, which we certainly don´t want."

It's also a great sleep aid. It knocks me out better than any precsribed sleep med and I've taken them all.

I'll sticky this - please keep adding to it guys

I stickied it. Now we can add then clean it up.

Viagra

First my experience and then info from the drug's maker.

Viagra: viagra is prescribed to men with ED (erectile disfunction). It is helpful for getting AND maintaining an erection. The nice thing about viagra, and most other ED drugs is that they generally (not always) only work when the subject is sexually aroused. In other words you can actually take viagra and be flacid but it doesnt take much to get things going. It usually takes about 30-90 minutes to kick in.

I have used viagra several times and it works just like it is supposed to. Usually takes about 30-40 minutes to kick in for me and lasts 3-6 hours. If you get a prescription for viagra (pretty easy), ask your doctor to presribe you 100mg tabs. you can break them into quarters and go up from 25mgs. its usually the same price for 25mg, 50mg and 100mg tabs so you get more BANG for your buck.

Info from Viagra's official site: VIAGRA has an established safety profile of over 9 years. It has been shown to work safely and effectively in men with ED. This includes:
-Men of all ages
-Men who have difficulty all the time or just some of the time
-Men with other health issues such as high blood pressure, diabetes, and depression.


VIAGRA is prescribed to treat erectile dysfunction (ED).

If you take any medicines that have nitrates in them (like nitroglycerin for chest pain)—every day or even once in a while—you should NOT take VIAGRA.

Discuss your general health status with your doctor to ensure that you are healthy enough to engage in sexual activity. If you experience chest pain, nausea, or any other discomforts during sex, seek immediate medical help.

Although erections lasting for more than 4 hours may occur rarely with all ED treatments in this drug class, to avoid long-term injuries, it is important to seek immediate medical help.

If you are older than age 65, or have serious liver or kidney problems, your doctor may start you at the lowest dose (25 mg) of VIAGRA. If you are taking protease inhibitors, such as for the treatment of HIV, your doctor may recommend a 25-mg dose and may limit you to a maximum single dose of 25 mg of VIAGRA in a 48-hour period.

In rare instances, men taking PDE5 inhibitors (oral erectile dysfunction medicines, including VIAGRA) reported a sudden decrease or loss of vision. It is not possible to determine whether these events are related directly to these medicines or to other factors. If you experience sudden decrease or loss of vision, stop taking PDE5 inhibitors, including VIAGRA, and call a doctor right away.

Sudden decrease or loss of hearing has been rarely reported in people taking PDE5 inhibitors, including VIAGRA. It is not possible to determine whether these events are related directly to the PDE5 inhibitors or to other factors. If you experience sudden decrease or loss of hearing, stop taking VIAGRA and contact a doctor right away.

If you have prostate problems or high blood pressure for which you take medicines called alpha blockers, your doctor may start you on a lower dose of VIAGRA.

Remember to protect yourself and your partner from sexually transmitted diseases.

The most common side effects of VIAGRA are headache, facial flushing, and upset stomach. Less commonly, bluish vision, blurred vision, or sensitivity to light may briefly occur

Levitra

First my experience and then some info from the drug's maker.

Levitra is similar to viagra in that its only active for a few hours. There are two noticeable differences between the two drugs in my personal experience. First, Levitra seems to kick in much faster than viagra which of corse can be a very good thing (usually 15-30 minutes). The down side that i noticed is that I couldn't orgasm or it took way too long. This can be a very good thing for some and i'm curious to see how this would work for somone who premature ejaculates. It actually seemed to give me a numb feeling. For those that do not have this problem, you may have to deal with comments such as "I can't make you come! Why don't I turn you on?" ect. ect. blah blah

info from Levitra's official site: LEVITRA is a prescription medicine that is used to treat erectile dysfunction (ED). Men taking nitrate drugs, often used to control chest pain (also known as angina), should not take LEVITRA. Such combinations could cause blood pressure to drop to an unsafe level.

As with all ED drugs, there is a rare risk of an erection lasting longer than four hours. To avoid long-term injury, seek immediate medical attention. LEVITRA does not protect against sexually transmitted diseases. In rare instances, men taking PDE5 inhibitors (oral erectile dysfunction medicine, including LEVITRA) reported a sudden decrease or loss of vision in one or both eyes, or a sudden loss or decrease in hearing, sometimes with ringing in the ears and dizziness. It is not possible to determine whether these events are related directly to these medicines or to other factors. If you experience any of these symptoms, stop taking PDE5 inhibitors, including LEVITRA, and call a doctor right away.

Discuss your medical conditions, including heart problems, and medications, including alpha blockers prescribed for prostate problems or high blood pressure, with your doctor to ensure LEVITRA is right for you and that you are healthy enough for sexual activity. LEVITRA is not recommended for men with uncontrolled high blood pressure.

The starting dose of LEVITRA is 10 mg taken no more than once per day. Your doctor will decide the dose that is right for you. In patients taking alpha blockers, your doctor may start you on a lower dose of LEVITRA. In patients taking certain medications such as ritonavir, indinavir, saquinavir, atazanavir, ketoconazole, itraconazole, erythromycin and clarithromycin, lower doses of LEVITRA are recommended, and time between doses of LEVITRA may need to be extended.

In clinical trials, the most commonly reported side effects were headache, flushing, and stuffy or runny nose. LEVITRA is available in 2.5-mg, 5-mg, 10-mg, and 20-mg tablets.

Thought i'd Add a little something.

ketoconazole - aka Nizoral shampoo

Hair loss benefits -

Nizoral shampoo has shown to be beneficial in men suffering from androgenic alopecia. One 1998 study showed that Nizoral 2% worked just as well as minoxidil 2% (brand name Rogaine) in men with androgenic alopecia. Both medicines increased hair thickness and increased the number of anagen-phase hair follicles on the scalp. Researchers were guarded about the meaning of these results, saying that more rigorous studies on larger groups of men should be done to confirm the findings, both to evaluate the ideal dosage and formulation, and to assess the desirability of routine treatment in this condition.

Results so far indicate that both the 1% and 2% dosages have positive hair loss benefits; however the more potent 2% formulation could have better results. Optimal usage is speculated at every third day, leaving the shampoo on the scalp for 3-5 minutes before rinsing. It has been stated that medications capable of maintaining the existing hair population should be regarded as effective treatments for androgenic alopecia. The present data suggests that ketoconazole should enter this group of drugs.

Source: wikipedia

HCG


Chorionic gonadotropin is a hormone found in the female body during the early months of pregnancy (it is produced in the placenta). It is in fact the pregnancy indicator looked at by the over the counter pregnancy test kits, as due to its origin it is not found in the body at any other time. Blood levels of this hormone will become noticeable as early as seven days after ovulation. The level will rise evenly, reaching a peak at approximately two to three months into gestation. After this point, the hormone level will drop gradually until the point of birth.

As a prescription drug, HCG offers us some interesting benefits. In the United States, we have the two popular brands, Pregnyl, made by Organon, and Lepori, made by Farma- Lepori, Spain. These are FDA approved for the treatment of undescended testicles in young boys, hypogonadism (underproduction of testosterone) and as a fertility drug used to aid in inducing ovulation in women. When prepared as a medical item, this hormone comes from a human origin. Although there is often a fear of biological origin products, there is little research to be found regarding pathogen or sterility problems with HCG. The problems seen with human origin growth hormone are certainly not to be repeated with HCG, as this compound is obtained in a much different way.

While HCG offers the female no performance enhancing ability, it does prove very useful to the male steroid user. The obvious use of course being to stimulate the production of endogenous testosterone. The activity of HCG in the male body is due to its ability to mimic LH (luteinizing hormone), a pituitary hormone that stimulates the Leydig's cells in the testes to manufacture testosterone. Restoring endogenous testosterone production is a special concern at the end of each steroid cycle, a time when a subnormal androgen level (due to steroid induced suppression) could be very costly. The main concern is the action of cortisol, which in many ways is balanced out by the effect of androgens.

Cortisol sends the opposite message to the muscles than testosterone, or to breakdown protein in the cell. Left unchecked (by an extremely low testosterone level) in the body, cortisol can quickly strip much of your new muscle mass away. The main focus with HCG is to restore the normal ability of the testes to respond to endogenous luteinizing hormone. After a long period of inactivity, this ability may have been seriously reduced. In such a state testosterone levels may not reach a normal point, even though the release of endogenous LH has been resumed.

Many who have suffered severe testicular shrinkage may be able to relate, as it is often some time before normal testicle size and feelings of virility are restored if ancillary drugs had not been used. The excessive stimulation brought forth by administration of HCG can likewise cause the testicles to rapidly return to their normal size and level of activity. We are not simply looking for it to fix the problem however, as the resulting high testosterone level can itself trigger negative feedback inhibition at the hypothalamus. Estrogen production is also heightened with the use of HCG, due to its ability to increase aromatase activity in the Leydig's cells. This is due to the main action of HCG, namely the increase of cycIicAMP (a secondary messenger that regulates cellular activity).

(continuation from above) ....



When stimulated by HCG, the ability of the testes to aromatize androgens could potentially be heightened several times greater than normal. This also may inhibit testosterone production, so we therefore use HCG only as a quick shock to the testes. The usual protocol is to inject 1500-3000 I.U. every 4'" or 5t" day, for a duration usually no longer than 2 or 3 weeks. If used for too long or at too high a dose, the drug may actually function to desensitize the Leydig's cells to luteinizing hormone, further hindering a return to homeostasis. Timing the initial dose is also very crucial.

If your were coming off a cycle of Sustaplex 325 (Blend of 5 Testosterone) for example, testosterone levels in your blood will likely stay elevated for at least 3 to 4 weeks after your last injection. Taking HCG on the day of your last shot would therefore be useless. Instead one would want to calculate the last week in which androgen levels are likely to be above normal, and begin ancillary drug therapy at this point. In this case HCG would be started around the third or fourth week. Likewise, after ending a cycle of Methanoplex (Methandienone) (an oral) your blood levels will be sub normal after the third day. Here you may want to begin HCG therapy a few days before your last intake of tablets, giving it a few days to take effect.

One would also want to give some thought to the level of suppression that the cycle might have brought about. After an 8 week cycle of Oxyplex (Oxymetholone)? for example, 1500-2500 I.U. would likely be a sufficient initial dosage. The lower amount of hormonal suppression one associates with this drug would probably not require much more. On the other hand, 750-1000mg of Sustaplex? per week might incline the user to inject a much larger HCG dose, perhaps as much as 5000 I.U. for the opening application. It may thereafter also be a good idea to reduce the dosage on subsequent shots, so as to step down the intake of HCG during the two or three weeks of intake. As discussed above, HCG acts only to mimic the action of LH. It is likewise not the perfect hormone to combat testosterone suppression, and for this reason it is used most often in conjunction with estrogen antagonists such as Clomiplex (Clomiphene Citrate) or Tamoxiplex (Tamoxifen Citrate)

These drugs have a different effect on the regulating system, namely inhibiting estrogen-induced suppression at the hypothalamus. This of course also helps to restore the release of testosterone, although through a much different mechanism than HCG. A combination of both drugs appears to be very synergistic, HCG providing an immediate effect on the testes (shocking them out of inactivity) while the antiestrogen helps later to block inhibition on the hypothalamus and resume the normal release of gonadotropins from the pituitary.

The typical procedure involves giving the Clomiplex, Tamoxiplex dose from the start with HCG, but continuing it alone for a few weeks once HCG has been discontinued. This practice should effectively raise testosterone levels, which will hopefully remain stable once Clomiplex, Tamoxiplex have been discontinued. While unfortunately there is no way to retain all of the muscle gains produced by anabolic steroids, using ancillaries to restore a balanced hormonal state is the best way to minimize the loss felt with ending a cycle.