RHODIOLA ROSEA .......

From my article:

"The mechanisms of action of Rhodiola rosea are many. These include antioxidant activity, propyl endopeptidase inhibition [2, 5], facilitation of monoaminergic activity, and opioid receptor activation. The enzyme propyl endopeptidase metabolizes various proline-containing neuropeptides including vasopressin, substance P, thyrotropin-releasing hormone, and alpha-melanocyte-stimulating hormone, all of which may play roles in learning and memory processes [5, 7]. Indeed, other propyl endopeptidase inhibitors improve spatial memory in animal models [7-8]. Rhodiola rosea may also inhibit monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) and facilitate the transport of neurotransmittors in the brain [1]. Another mechanism of action is the release of endorphins. Russian research indicates that Rhodiola rosea induces opioid peptide biosynthesis by activating opioid receptors in both the central and peripheral nervous system [1]."

The "may" in reference to MAO and COMT is a very big "may." This effect has been theorized because rhodiola leads to various changes in monoamine levels in rats - both increases and decreases, depending on the area of the brain. It is much more likely that this is downstream to other effects of rhodiola. IOW, there is no solid evidence that rhodiola even has these effects yet. The mechanism of action is primarily related to it's effects on various peptides.

Rhodiola does not raise blood pressure. In fact it reduces blood pressure increases caused by various stressors.

Rhodiola's cardioprotective effects are due to increases in opioid peptides and antioxidant effects.

Rhodiola is not a "stimulant," unless you define the word quite loosely. It does not fit under the drug category though. It increases resistance to situations that cause fatigue, but does not have any significant direct stimulating properties. Thus the term "adaptogen."

No, there are specific criteria a substance must meet to be termed an adaptogen, dobutamine does not meet these.

The original research is in Russian. Many of the abstracts can be found on pubmed, but not the full texts.

Where did this come from? Was whoever wrote it trying to pass it off as something they wrote themselves?

Anyway, I covered this above.

Literally tons of the substances in foods we eat, and in drugs we take are MAOI's. It only really matters if a drug is a particularly potent MAOI. So you can't really extrapolate much just from knowing that a drug is an MAOI. It depends on the isoenzyme it inhibits, and what the potency is in various tissues in vivo. And like I said the MAO effect of rhodiola is purely theoretical. There are plenty of other things that more adequately explain its effects.

This is all completely 100% wrong.

Can you point me to where this was posted?

Serotonin syndrome can occur when multiple drugs that increase serotonin concentrations/sensitivity are combined.

It is quite uncommon.

yeah, it was over at avant, I was skeptical of this guy's finding s to say the least as I have had nothing but good results with rohodiola as of yet. I think I was coming down with a slight virus or something that was making me tired. No biggy though....
Shplonged, so you do not see any inherent issues with stacking rhod and HEAT?

I don't see any problems, no - but I don't know a lot about the ingredients in HEAT.

200-500 mg split between 1-3 doses.

Unfortunately, if RR does become popular enough to somewhat replace SSRI's, the pharm industry will have the FDA ban it as a "dangerous" supplement.

No one could answer that with certainty. Unlike a pharmaceutical entity, herbals such as rhodiola contain a diverse pool of psychoactive substances - some or many of which being poorly understood. What I said above also applies to the issue of pharmaceutical entities and herbal counterparts.

A potential for a negative interaction does exist, as it would seem. As with all things, that depends on the individual.

Thank you for the reply guess ill have to try and see.I'll let you know how it goes.

Well said. I hope stuff that works never becomes popular or the pitbulls (politicians) will ban it as per their masters wish (pharmaceutical industry)

I agree. RR is actually better for me anyway taken at smaller dose . I take 1 large capsule packed tightly and thought I was crazy but did /still do notice energy from it great pre workout supplement.

Trick is to much you feel to relaxed not what you want pre workout if thats what you take it for. When I took 2 capsules felt like taking it easy at 1 capsule an hour later cant wait to get to gym.

For some one packed large capsule might be to much or not enough. Its underrated stuff . Nasty tasting but I cap it.