ephedrine and yohimbine

Bulk Nutrition Forums > Supplements



Posted by: powergrudge Mar 23 2004, 04:56 PM
I've heard some people recommend adding yohimbine into an ephedrine-based fat burning stack to make it more effective, but I've heard others say that this is counter-productive. I found this explanation posted on ruggedmag.com:

QUOTE
Yohimbine is an a2 antagonist; a2 receptors are AGONIZED by epinephrine which in turn causes activation of the Gi protein, not the Gs. (beta receptors activated by epi and norephi acitvate the Gs (stimulatory) protein))
Thus, you want low levels of A2 agonism so that the Gi protein is not activated causing inhibition of lipolysis (i=inhibition).
ECA agonizes both beta and alpha receptors. Great for beta, not for alpha. Thus, if you had agonism at the general celluarly level, yohimbine won't make much difference.

The only exception is MILD agonism and yohimbine. Even then, any agonism of alpha receptors will result in activation of the Gi protein.
Yohimbine is best taken in absentia of ECA AS WELL AS en absentia of intense cardiovascular exercise. The lower the circulating chatecholamines, and insulin, the better time to take Yohimbine. For example, go hypocaloric and take Yohimbine in the morning, particularly if you have a computer job. The hormonal millieu vis a vis hypocalorie/keto and low chatecholamine levels are best for a2 destruction.


Does this explanation hold up? If so, why do some popular products (Lipo 6, Clenbutrx, etc.) contain both compounds and why do people seem to get good results from these stacks?

Posted by: MaynardMeek Mar 23 2004, 06:31 PM
If you do, start slow and low. Yohimbine and Ephedrine togeather can wack you the hell out to the point of not being able to do anything. But I use the two with each other, its it is very nice. But like all things, keep the feasting clean


Posted by: shpongled Mar 23 2004, 09:06 PM
QUOTE (powergrudge @ Mar 23 2004, 04:56 PM)
Does this explanation hold up? If so, why do some popular products (Lipo 6, Clenbutrx, etc.) contain both compounds and why do people seem to get good results from these stacks?

Here is my opinion on this.

First, there is no way to really know for sure the interaction between yohimbine and ephedrine when humans take it, as there are so many arguments both ways. The only thing that is known for sure is that they additively increase stress on the cardiovascular system.

Second, you definitely can't take the ingredients in most popular products as indications of what works, as they put what people think works in the products, not what is actually known to work.

Third - and I know this is an opinion many disagree with - I don't put much stock at all in reports of results from people (unless we are talking about steroids/prohormones). There are so many different factors, that it is difficult to ever isolate the fat burner you are taking as the sole cause of fat loss. People often give positive feedback based on their perception of what a fat burner should be like - I've noticed that if something makes the person feel wired, they will think it is a potent fat burner, even if it's not. This is why many companies hide large amounts of caffeine in their products, even though caffeine is not a very effective fat burner by itself. They know that people will "feel it working." And, with ephedrine and yohimbine, you will definitely "feel it." But this isn't necessarily indicative of positive results.

Personally, I recommend against combining the two, for safety reasons - ephedrine (with caffeine) is very effective, and the effectiveness will increase pretty much linearly up until about 100-150 mg, so if you aren't taking that much, then just increasing the dosage will increase your results. It is best to keep it simple, and that way you can guage exactly how you are reacting to the compound, without having to guess which one is causing a certain effect.

Posted by: powergrudge Mar 25 2004, 01:17 AM
QUOTE (shpongled @ Mar 23 2004, 09:06 PM)
Third - and I know this is an opinion many disagree with - I don't put much stock at all in reports of results from people (unless we are talking about steroids/prohormones). There are so many different factors, that it is difficult to ever isolate the fat burner you are taking as the sole cause of fat loss. People often give positive feedback based on their perception of what a fat burner should be like - I've noticed that if something makes the person feel wired, they will think it is a potent fat burner, even if it's not. This is why many companies hide large amounts of caffeine in their products, even though caffeine is not a very effective fat burner by itself. They know that people will "feel it working." And, with ephedrine and yohimbine, you will definitely "feel it." But this isn't necessarily indicative of positive results.

Well said.

So you would recommend against adding ephedrine to something like Lipo 6 EF or Tight?

Posted by: shpongled Mar 25 2004, 10:31 AM
QUOTE (powergrudge @ Mar 25 2004, 01:17 AM)
QUOTE (shpongled @ Mar 23 2004, 09:06 PM)
Third - and I know this is an opinion many disagree with - I don't put much stock at all in reports of results from people (unless we are talking about steroids/prohormones). There are so many different factors, that it is difficult to ever isolate the fat burner you are taking as the sole cause of fat loss. People often give positive feedback based on their perception of what a fat burner should be like - I've noticed that if something makes the person feel wired, they will think it is a potent fat burner, even if it's not. This is why many companies hide large amounts of caffeine in their products, even though caffeine is not a very effective fat burner by itself. They know that people will "feel it working." And, with ephedrine and yohimbine, you will definitely "feel it." But this isn't necessarily indicative of positive results.

Well said.

So you would recommend against adding ephedrine to something like Lipo 6 EF or Tight?

Yeah. Given a choice, I prefer ephedrine because it is less expensive and the effectiveness is proven. OTOH premade stacks are more convenient. Alternating two weeks cycles of each may be most effective for appetite suppression.

Posted by: Armond May 11 2004, 12:00 PM
Ok I have heard a few different things about when/how to take Ephedrine, Caffeine, and Yohimbine.

Could someone please describe for me the procedure/schedule for taking the stuff? I would like to know optimal time periods, and which ones to take together! If they should be taken after meals, during meals, how long after meals, on an empty stomach, and mixing which ones together.

Also they say yohimbine should be taken a couple times at night so you don't walk around with an erection, and so your body can get used to it. Does that statement hold any validity?

Sorry, I am just trying to figure this stuff out.

Thanks for your help,
Armond

Posted by: Skate May 11 2004, 12:14 PM
QUOTE (Armond @ May 11 2004, 12:00 PM)
Ok I have heard a few different things about when/how to take Ephedrine, Caffeine, and Yohimbine.

I'm not running Yohimbine in my stack, but as far as EC goes I take 25mg ephedrine with 200mg caffeine 3x day. Usually once in the morning, once at lunch time and once 30-45 minutes before working out. Ideally you would want to try and spread out the doses fairly evenly throughout the day. IMO, it doesn't matter much if you take it with or without food. Only thing I ever notice is that if I take it either right before/after I eat, the jittery effect is reduced.

Posted by: weeviekins2000 May 11 2004, 12:26 PM
I just purchased some more vasopro, and got some caffine and yohimbine hcl with it. I have been taking the vasopro for a while now, and wanted to add some stuff for more of an energy "kick". Today was the first time and I added one 1fast caffine and 1 1fast yohimine hcl, it really only made a slight difference, but I am being careful and starting with a low dose of yohimbine hcl. So what dose should I be using?. Should I add another yomibine hcl to my next dose?. I don't want to freak out or anything because the first time I took the vasopro I freaked out and almost had a panic attack, but now it seems to not do very much in the way of energy. I figure if I start slow with the yomibine I can get a little extra "kick" without freaking out...So should I stick with one pill of each or bump up the yohimbine today, tommorow, or next week?

Posted by: weeviekins2000 May 11 2004, 07:15 PM
bump

Posted by: mudger May 11 2004, 07:53 PM
I just ordered Lipo-6 EF and Vasopro and I wanted to know how much should I take daily and for how long? I never took either before.

I am 18 Just finishing up HS: 165, 6'0"

Posted by: Armond May 11 2004, 11:38 PM
thanks Skate, I needed some of that info. I will spread it out for 3 times a day. Sounds good to me! the Yohimbine and caffeine, I will take that when I first wake up, and then wait some time(2 hours?) before I eat(I will take the Ephedrine and the caffeine then).

thanks again,
Armond

Posted by: Skate May 12 2004, 09:27 AM
QUOTE (mudger @ May 11 2004, 07:53 PM)
I just ordered Lipo-6 EF and Vasopro and I wanted to know how much should I take daily and for how long? I never took either before.

I am 18 Just finishing up HS: 165, 6'0"

Welcome Armond cool.gif

As far as the Lipo & Vasopro goes, go with label recommendations since this is the first time you've used these. IMO, start off easy. You might want to just take the Lipo by itself for the first few days, then start adding in the Vasopro. If you get any "jitters" you can always try taking them with food...that may help some.

Once you work your way up on dosage levels, I'd say go with 2-Lipo + 1 Vasopro 3x a day, once being 30-45 minutes before workout. Again, that's just my opinion.

Posted by: Armond May 12 2004, 11:35 AM
I woke up this morning and took the Yohimbine with the Caffeine, and so far no problems.

but then now I come across a situation... I read the caffeine bottle, it says no more than 3 times a day.

So is taking the Ephedrine with the Caffeine only twice a day going to have an effect? Or should I just go for the three times a day, and disregard the directions on the caffeine?

Schedule:

9am Take Y with C
Noon Take E with C
3pm Take E with C
6pm Take E with C

Is that ok? I will be eating regularly from 11am to about 7pm. Does that sound like a good idea? If so I may have to order more Caffeine and Ephedrine pills... I only bought one bottle of each. So the most amount of days I can do this is 20 days. At least based on the plan above.

Just needed some more advice, sorry if I keep asking, just want to have a clear cut plan!

thanks,
Armond

p.s. I heard that me weighing 160 lbs, I will have to take about 15mg of Yohimbine. Is this true, and if so, then the one pill bottle will only last about 15 days. So basically I will have to reorder in 15 days a little bit of everything!


Posted by: Skate May 12 2004, 11:45 AM
Well, if money starts becoming an issue you can check into buying bulk powders. Can't get the Vasapro that way, but you can with the other two (check this link out for more info: http://www.bulknutrition.com/?cPath=78)

As far as caffeine goes, you don't want to really go way over 600mg a day (3 tabs a day if you have the 200mg dose type). I'd try to stay in a range between 6-800mg a day total. Going over really isn't going to do anything "extra" for you. Try reading the article about caffeine in the articles section. Granted if you start hitting 1000mg+ a day you may start having some problems, but read the write-up for a good explanation.

One thing to keep in mind also regarding caffeine. If you drink a lot of pop/soda you need to figure that in as well. As a little F.Y.I. something like Diet Coke has around 45mg caffeine in a 12oz can. Think Mt Dew is up around 60 something if I remember right. Like I said, if you're in the 6-800mg range you should be fine.

Posted by: Skate May 12 2004, 11:51 AM
Btw...your dosage schedule looks pretty good. If you need to drop the caffeine levels for the day down I'd drop the dose with the yohimbine.


Posted by: Armond May 12 2004, 11:58 AM
Hey skate you rock bro, I do not drink any soda, and no coffee whatsoever. I drink water only throughout the day, no type of sodas or soft drinks.

I have been doing that for about 3 months now. Well I lied, I drink maybe, and this is a huge maybe, one soda a week. I just have no taste for it anymore! i guess that is a good thing eh?!

So my schedule is good? Great, I will stick to it.

And I think I will stick with pills man, powders really make me sick. Guess i wil order some more stuff!

Later,
Armond

p.s. skate I may call on your help sometime in the future again! thanks for the replies!


Posted by: Skate May 12 2004, 12:14 PM
Anytime bud...you can always send a pm to my inbox if you need to.

You should be fine then with your caffeine levels. I just usually mention that cause one guy on here was a Diet Coke freak and drank a lot so it's something I keep in mind now.

Understand how you feel about powders. Sometimes you can get away by masking the taste of the powder by mixing it in something like Kool-Aid or Crystal Lite.

Posted by: Armond May 13 2004, 01:02 AM
Well, I went the whole day with the schedule. I was wired...

I think I am going to drop the last usage of caffeine and ephedrine. I think it is a little much. So basically I am going to put another hour between the 1st and 2nd dosage of ephedrine, and see how that feels.

So like this:

9am Take Y with C
Noon Take E with C
4pm Take E with C

Thanks for all the help!


Posted by: Jeffrey Doane Jan 3 2005, 11:03 PM
Is yohimbine pretty affective on its own with caffine pills????? i take 6 yohimbine pills in the morning and 1 caffine pill... then 1 caffine pill before workout... I was thinking about takeing some ehedrine with it but..... i would like some more info